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doi:10.1016/j.maturitas.2019.11.001

The role of site rotation Injecting repeatedly in the same area can irritate tissue, causing both bruising and small lumps (lipohypertrophy) that reduce absorption

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Pregnancy and lactation: Avoid use during pregnancy or breastfeeding unless controlled human data show safety

Pharmacological stimulation of gonadotropin secretion, antioxidant-based interventions, and assisted reproductive techniques may enable partial recovery in selected cases